However, it was unexpected that hypermethylated genes would continue to be repressed after UHRF1 depletion, as it is well documented that UHRF1 acts as a hub to recruit multiple proteins, including DNMT1, HDAC1, G9a, and EZH2, to repress cancer-associated genes in cancer cells [15, 21, 22, 34]. Here, UHRF1 is linked to cancer.