Conversely, methylation-mediated silencing of miR-340-5p enhanced myeloma plasma cell proliferation via upregulation of CCND1 and MAPK signaling (NRAS/MEKK1/MEKKK3/p-ERK) in addition to enhancing myeloma cell survival by targeting XIAP. The gene discussed is CCND1; the disease is plasma cell myeloma.