MICA and ovarian neoplasm: γδ T cells can limit the proliferation of ovarian tumor cells by downregulating apoptosis and cell cycle-related molecules, while γδ T cells combined with induced ATM/ATR signaling could enhance the cytotoxicity to OC cells; moreover, ovarian tumor cells could escape γδ T cell-mediated recognition by upregulating pERK1/2 and downregulating surface MICA levels [29, 30].