Overexpression of FBXW7 inhibited sphere formation, CD133, CD44, OCT4, cyclinD1, c-myc, N-cadherin and increased E-cadherin in miR-92a-3p expressing CRC cells, leading to inhibition of cell stemness, proliferation and EMT phenotypes (Fig. 4l-n, Additional file 1: Figure S7E, F, ** P < 0.01). The gene discussed is PROM1; the disease is colorectal carcinoma.