We also found that SW480CAFs-exos, SW620CAFs-exos and LOVOCAFs-exos cells expressed higher mesenchymal markers (N-cadherin and Vimentin) and lower epithelial markers (E-cadherin) compared to SW480NFs-exos, SW620NFs-exos and LOVONFs-exos cells, suggesting the induction of epithelial to mesenchymal transition in CRC cells by CAFs-exos (Fig. 1l). This evidence concerns the gene VIM and colorectal carcinoma.