Since EpCAM, a cell surface molecule, is found to be overexpressed in cancers, Subramaniam et al. (2015) employed a novel aptamer-polyethyleneimine (PEI)-siRNA nanocomplex to target EpCAM in MCF-7 and retinoblastoma cell line (WERI-Rb1). The gene discussed is EPCAM; the disease is retinoblastoma.