ATF4 and neoplasm: Inhibition of the PERK/eIF2α/ATF4 signaling axis with acriflavine (an antiseptic agent that also targets HIF1 pathway) prevents EMT at the cellular and molecular levels (i.e., no change in cellular morphology and no induction of EMT markers as such E-cadherin, vimentin, SNAI1, SPOCK1 and TWIST1); and inhibits the tumor cell migration (Figure 2, (2)) [165].