Interestingly, TRAM2 (for translocation associated membrane protein 2), a component of the SEC61 translocation channel located at ER, is highly expressed in oral squamous cell carcinoma and has a main role in metastasis by controlling PERK activation and the expression of MT1-MMP, MMP2, and MMP9 [155]. This evidence concerns the gene TRAM2 and oral cavity squamous cell carcinoma.