Although our findings do not exclude the possibility that additional laminin 511 is provided by endothelial, perivascular cells or fibroblasts, the profound effect on vascular morphology and function upon inhibition of LAMA5 expression specifically by colon cancer cells indicates that cancer cell laminin 511 deposition itself is indeed important for tumour angiogenesis. The gene discussed is LAMA5; the disease is colonic neoplasm.