In addition, at 10–60 μM fisetin concentration, prostate cancer cells PC3, LNCaP, and CWR22Ry1 had decreased cellular viability and decreased levels of D1, D2, and E cyclins and their activating partners CDK2, and CDKs 4/ 6, with consequent induction of KIP1/p27 and WAF1/p21 [53]. The gene discussed is CDKN1A; the disease is Familial prostate cancer.