Mechanistically, regulation of the release of cytochrome c from mitochondria, caspase-3 and caspase-9 mRNA and protein expression, and B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X (Bax) levels, were found to be regulated in the fisetin-treated cancer cell line (oral squamous carcinoma) [44]. This evidence concerns the gene CYCS and cancer.