AKT1 and triple-negative breast carcinoma: The in vitro findings from another study by Li et al. concluded that fisetin could significantly overpower growth and metastasis in MDA-MB-231 and BT549 triple-negative breast cancer cell lines, thereby blocking the EMT process induced through the phosphatase and tensin homolog/protein kinase B/glycogen synthase kinase 3 (PTEN/Akt/GSK-3β) signaling pathway [111].