PTEN and acute lymphoblastic leukemia: Upregulated FAK activity was observed in both Pten-deleted murine thymocytes and human PTEN-null T-ALL cells [121], where it elicited survival signals via a receptor activating protein 1 (RIP1)/nuclear factor-κB (NF-κB)/B-cell lymphoma-extra-large (Bcl-xL)/B-cell lymphoma 2 (Bcl-2) signaling axis [122] (Figure 1).