A work from Rogenski’s laboratory (17) showed that 15-PGDH knockdown in 9027 shRNA lentivirus-infected RT4 cells permitted PGE2 signaling as measured by cAMP generation, whereas signaling was suppressed in the 15-PGDH-ex-pressing parental lines, demonstrating that 15-PGDH had a direct impact on PGE2 signaling in cancer cells. Here, HPGD is linked to cancer.