Wang J‐J, et al verified that exosomes secreted from macrophages infected with mycobacterium avium contained upregulated CYPA.39 In prostate cancer cell, CYPA was present as a housekeeping protein in exosomes.40 In this study, we also proved that CYPA present in serum exosomes from NPC patients. The gene discussed is PPIA; the disease is nasopharyngeal carcinoma.