PPIA and cardiovascular disorder: CYPA is a member of the immunophilin family with peptidyl prolyl cis‐trans isomerase (PPIase) activity, which is in close relationship with many physiological and pathological activities including protein folding and trafficking.8, 9 CYPA has been shown to be associated with various diseases such as cardiovascular disease, kidney disease, viral infection and cancer by binding with membrane receptor or intracellular partners and activating downstream signaling pathways.10, 11, 12, 13, 14