PGF and colorectal carcinoma: Several blood‐based protein biomarkers, such as CEA, CA19‐9, and CA242, have been associated with the diagnosis of CRC; however, none of these proteins have individually been able to detect the majority of early‐stage or proximal CRC.7, 34 This study was aimed to evaluate the effectiveness of CRC screening using serum PlGF level alone and also focusing on its addictive effect for stool OB negative group, with a multi‐centers, two stages study.