The linear regression analysis showed that the serum level of creatinine was found to correlate positively with NIHSS scores in AIS patients with AKI, and the similar correlation between serum NGAL and the NIHSS score also suggested that the levels of serum NGAL and creatinine may reflect the severity of AIS patients with AKI (Figure 4A, 4B). This evidence concerns the gene LCN2 and androgen insensitivity syndrome.