PRKAA2 and metabolic disease: 40 Although the AMPK knock down model is more significant, missense mutations or subunit‐deficient AMPK cause hypertrophic cardiomyopathies, heart failure, atrial fibrillation, ventricular arrhythmia and other metabolic diseases.41 It can't match the clinical diagnostic standard of ICM and will interfere with our observation of ICM.