The activation of AMPK appears to have a protective effect on many heart diseases by adjusting energy metabolism and the immune system,13 such as attenuating the development of atherosclerosis by reducing Drp1‐mediated mitochondrial fission.14 And Krawczyk et al implicated AMPK as an inhibitor of DC activation that modulated inflammation response.15 The gene discussed is PRKAA2; the disease is heart disorder.