NR1H4 and gallstones: The rs35724 G/G, G/C, and C/C genotypes were reported to be prevalent in 37%/45%/17% in European patients, which was confirmed by our study.15 While the functional effect of the FXR rs35724 SNP is currently unknown, one study reported a higher prevalence of the C/C genotype in male gallstone carriers, although there was no impact on the expression of genes involved in bile synthesis and transport.18 Our study uncovered a significant association of rs35724 minor allele and improved survival in the overall cohort and subgroups of different disease severity.