In line with our observations, Mueller et al. (2017) reported a better liver function and improved survival in 341 patients with dACLD and ascites harboring rs35724 minor allele.26 Just recently, Grimaudo et al. reported significantly higher hepatic FXR mRNA levels associated with the rs35724 minor alleles—together with higher levels of circulating cholesterol and lower carotid artery intima‐media thickness of the common carotid arteries in a cohort of 124 patients biopsy‐proven non‐alcoholic steatohepatitis (NASH). Here, NR1H4 is linked to metabolic dysfunction-associated steatohepatitis.