PNPLA3 and Hepatic fibrosis: For a better understanding of modulators of liver disease progression, genetic factors have been increasingly investigated: For example, the PNPLA3 rs738409 (C > G) SNP has been associated with an increased risk for hepatic decompensation and liver‐related mortality.12, 22 Additionally, the G‐allele is associated with steatosis, liver fibrosis, and disease activity in non‐alcoholic fatty liver disease23 and viral hepatitis.24, 25