B2M and neoplasm: As 95% (110 of 116) of the tumours tested were stage II, consistent with the 91% overall proportion of stage II CRCs in QUASAR, we could not meaningfully compare propensity for nodal spread in B2M‐mutant and wild‐type tumours: 2.6% (one of 39) versus 3.9% (three of 77) were node‐positive.