However, not all PTEN-positive glioblastoma cells had low p-AKT1/ENTPD5 levels, whereas WT PTEN-expression in LNT229 glioblastoma cells was responsible for their low p-AKT1/ENTPD5 levels (Fig. 4b); LN18 cells retained high p-AKT1/ENTPD5 levels even in the presence of WT PTEN [Suppl. The gene discussed is AKT1; the disease is glioblastoma.