The principal findings were as follows: (1) PTX3 provided clinically relevant diagnostic accuracy as a single marker for predicting fibrosis stages; (2) the accuracy of PTX3 levels for diagnosing significant (F≥2) liver fibrosis, measured as sensitivity, specificity, PPV, and NPV, was significantly higher than the accuracy for the GPR ratio (AUC = 0.648) and FIB-4 score (AUC = 0.770) and similar to that for the APRI index (AUC = 0.831) and HA (AUC = 0.891). Here, PTX3 is linked to Hepatic fibrosis.