The highest annual rate of stroke and systemic embolism (2.45%) was found in the group with CHA2DS2VASc score 3 and NT-pro BNP level >1250 ng/L compared to the averaged annual rate of stroke 0.56% in CHA2DS2VASc < 2 and level of NT-pro BNP < 363 ng/L. The gene discussed is NPPB; the disease is stroke disorder.