Reduced uPAR on neutrophils was particularly found in AKI stages II (n = 11, neutrophilic uPAR expression median 41.7%) and III (n = 28, median 44.5%), which was mirrored by significantly increased serum suPAR (AKI II, median 12.26 ng/ml; AKI III, 13.58 ng/ml) (Fig. 2c). This evidence concerns the gene PLAUR and acute kidney injury.