By the end of Phase 1 (wk 10), body weights, visceral fat, total body fat (sum of dissected fat), % body fat (total body fat × 100%/ body weight) (p < 0.01), hepatic lipid levels (p < 0.05, Table 2) and plasma leptin levels (p < 0.001) were greater in HF1 vs. LF rats, demonstrating that HF1 rats were obese and had hepatic steatosis (> 5% of liver weight as lipid) at the end of Phase 1. The gene discussed is LEP; the disease is fatty liver disease.