A gene signature including the top 10 genes (see Supplementary Methods for gene names in the signature) induced by CBFB and RUNX1 significantly predicted the Disease-Free Survival Probability of breast cancer patients from TCGA (The Cancer Genome Altas)24 and the Disease Specific Survival of breast cancer patients from METABRIC25 (Fig. 7b and Supplementary Fig. 8a). The gene discussed is CBFB; the disease is breast cancer.