Furthermore, in line with previous studies, the expression of FoxP3 in encephalitogenic T-cells from RR-EAE mice was significantly higher than in T cells from the brains of CP-EAE mice at the peak of disease, indicating a more immune-tolerant environment, which has been shown to coincide with and drive episodes of remittance in both human MS and mouse models21 (Supplemental Fig. S2B). This evidence concerns the gene FOXP3 and myeloid sarcoma.