METTL3 and liver cancer: METTL3, which is the methyltransferase of mRNA m6A, exhibits several functions in cancer cells, such as: maintaining myeloid leukemia48, promoting liver cancer progression49, playing essential role in GSC maintenance and radioresistance50, positively regulating proliferation of hematopoietic stem/progenitor cells (HSPCs)51, and triggering the translation in cancer cells52.