This is in accordance with mitochondria-enriched data, where among regulated proteins, several enriched subunits of ETC complex I showed the main functional category and decreased abundance in the tumor samples (Fig. 6d), and four of them are, in fact, identified as best performing markers of tumor tissue for this mito dataset (i.e., Ndufs4, Ndufb3, Ndufb9, and Ndufv2; Fig. 6a). This evidence concerns the gene NDUFS4 and neoplasm.