As seen for IL-37 (Fig. 2a), several other anti-inflammatory markers, namely Foxp3 (P = 0.012), Ym1 (P = 0.006), Il-10 (P = 0.018), Il-13 (P = 0.002) and Tgfb (P = 0.008) were up to 3-fold increased in the ischemic hemisphere following stroke in IL-37tg compared to WT mice (Fig. 5A–E). The gene discussed is IL13; the disease is Stroke.