A key regulator of ER-stress and UPR, the orosomucoid 1-like protein 3 (ORMDL3), has been shown to regulate airway remodeling through a major UPR protein, activating transcription factor 6 (ATF6), but the contribution of this regulatory axis on compensatory pancreatic beta cell proliferation in diabetes has not been studied. The gene discussed is ATF6; the disease is diabetes mellitus.