ORMDL3 and asthma: An association between ORMDL3 and asthma has been reported in a genome-wide association study [7], and later studies have shown that ORMDL3 may regulate airway remodeling through activating transcription factor 6 (ATF6), a critical transmembrane sensor for ER stress, and its downstream gene SERCA2b [9, 10], or through transforming growth factor β (TGF-β) [10] or metalloproteases [9].