TOP2A and familial pancreatic carcinoma: Combined the results of expression analysis and survival analysis, we found that 7 upregulated hub genes (MMP9, CXCL8, ACTB, ITGB1, STAT1, TOP2A and CDK1) were not only significantly upregulated in pancreatic cancer samples but also the increased expression of the 7 genes indicated poor prognosis in patients with pancreatic cancer (Figure 5A and Figure 5C-I), and 2 downregulated hub genes (GNMT and ABAT) were commonly appeared in “low expression” gene set and “good prognosis” gene set (Figure 5B and Figure 5J-K).