MMP9 and familial pancreatic carcinoma: For example, MMP9 participated in pancreatic cancer angiogenesis and invasion [34,35]; CXCL8 promoted invasiveness and angiogenesis in pancreatic cancer [36]; ITGB1 was upregulated in pancreatic cancer and increased ITGB1 indicated a poor outcome [37]; and STAT1 enhanced pancreatic cancer growth and metastasis [38].