Due to the discrepancy between its high potency in cellular assays (at low micromolar/submicromolar level for the reactivation of genes silenced by promoter DNA methylation and the effects on cell viability in a panel of cancer cell lines) and its biochemical DNMT inhibition (micromolar range), MC3353 was screened against a panel of 46 kinases (ExpresS Diversity Kinase Profile, Cerep), taking into account its structural similarity (presence of aminoquinoline, p-aminobenzoic, and benzene-1,4-diamine fragments) with kinase inhibitors. This evidence concerns the gene DNMT1 and cancer.