Then, it was tested in a stable cellular luciferase cytomegalovirus (CMV) reporter system (CMV-luc) integrated in human leukemia KG-1 cells in which the luciferase gene is under the control of the methylated CMV promoter, as well as in HCT116 human colon cancer cells to detect its ubiquitin C-terminal hydrolase L1 (UCHL1) promoter demethylating ability, revealed by enhanced green fluorescent protein (EGFP) reporter gene expression. This evidence concerns the gene UCHL1 and malignant colon neoplasm.