UCHL1 and colonic neoplasm: In parallel to this expression induction effect in leukemia cells, in HCT116 cells, MC3353 was able to strongly induce EGFP gene expression (81.4%), which is under the UCHL1 promoter, silenced by methylation in colon cancer, hence underlining its specific demethylating activity at a very low concentration (0.1 μM).