For instance, we showed that interferon-γ gene expression was associated with TMB in both NSCLC and urothelial carcinoma patients [23], and separately that the prevalence of patients with high levels of PD-L1+ cells as well as CD8+ cells, based on a different image analysis measure than that reported here, correlated with TMB across multiple tumor types [47]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.