We also found a similar finding in lobular cancer where LCIS had a stronger association with CHEK2 mutations than ILC (ILC OR = 4.29, 95%CI 1.60–11.51, P = 0.0017; LCIS OR = 9.95, 95%CI 3.44–28.82, P = 5 × 10−5, Petridis et al. accepted Cancer Epidemiology, Biomarkers & Prevention). Here, CHEK2 is linked to cancer.