The other nine patients (9/24) (No. 13, 14, 15, 19, 20, 22, 29, 24 and 31) met the diagnosis of hypergonadotropic hypogonadism according to basal FSH levels, except for No. 24 and No. 31, whose basal FSH levels were 33.61 IU/L and 35.71 IU/L at the age of 3.5 and 4.0 years, respectively. Here, BRD2 is linked to Hypergonadotropic hypogonadism.