In clinical samples from the Grasso [45] and MSKCC [46] datasets, the expression of the individual genes from the TMCC11 signature is significantly increased in CRPC and metastatic disease samples when compared to normal tissue, and inversely correlated with the expression of TMEFF2 in the same samples (Additional file 1: Figure S5A and S5B). Here, TMEFF2 is linked to metastatic neoplasm.