BRCA2 and breast cancer: Genetic variation analysis of BRCA2 has identified a large number of different pathogenic germline variants in breast cancer patients and more than a thousand different disease–causing germline pathogenic variants were listed in the Breast Cancer Information Core Database (BIC; http://research.nhgri.nih.gov/bic/) and in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar/).