INS and obesity due to melanocortin 4 receptor deficiency: 2019). The severity of lipid disorders in diabetic patients depends on the level of insulin secretion, insulin resistance, obesity, diet and the presence of underlying or secondary causes of hyperlipidaemia. Hyperlipidaemia exacerbates hyperglycaemia-induced oxidative stress and related tissue damage through increasing serum and tissues free fatty acids (FFA) (Xu et al. 2019).