In a mouse model of NASH-HCC (CDE diet), PGC-1α expression was reduced within the tumors, as well as in human HCC samples [114].The authors have shown that PGC-1α and other gluconeogenesis genes were reduced by miR-23a in experimental and human HCC, however, they did not investigate the effect of PGC-1α-targeting by miR-23a on mitochondrial biogenesis [114]. The gene discussed is PPARGC1A; the disease is hepatocellular carcinoma.