Moreover, in vitro studies demonstrate that NRF2-silenced HCC cells down-modulate hexokinase 2 (HK II), citrate synthase (CS), TNF receptor associated protein 1 (TRAP1) and HIF-1α, further indicating a central function of NRF2 as in metabolic rewiring [162]. The gene discussed is HK2; the disease is hepatocellular carcinoma.