However, yes-associated protein 1 (YAP-1) repression of PGC-1α did not affect the expression of mitochondrial genes, suggesting that inhibition of gluconeogenesis, rather than remodeling mitochondrial function, promotes tumor growth by diverting substrates away from the energy-consuming processes of gluconeogenesis and toward anabolic pathways [121]. Here, PPARGC1A is linked to neoplasm.