Intriguingly, a high salt diet seems to accelerate the progression of lupus in MRL/lpr mice but not MRL/mpj and Balb/c mice, and, finally, NaCl seems to induce DNA hypomethylation of CD4+T cells and to enhance the expression of the hydroxyltransferases TET2 and TET3. The gene discussed is CD4; the disease is systemic lupus erythematosus.