The diversity of nAChR subtypes enables them to regulate a variety of important physiological or pathological processes [4] including cancer [5], neurological disease [6], addiction [7], inflammation [8], pain [9], etc. The α9α10 nAChR is a newly discovered subtype, recently verified as a novel analgesic target to treat neuropathic pain [10,11]. Here, CHRNA4 is linked to cancer.