To test if cytoxicity of KDM5 inhibitors were related to overexpression of KDM5B which plays a chemoprotective role in MCF7 cells, we tested the effects of the three drugs on other two breast cancer cell lines: MDA-MB231 which does not overexpress KDM5B and T47D which shows a slightly lower expression compared to MCF-7 (SM Figure S11). This evidence concerns the gene KDM5B and breast carcinoma.