In METABRIC study, breast cancer tumors (2173 tumors) were 69% ER+, 48% PR+, and 80% HER−, representing a mixed subtype, in which amplification of the StAR gene (~12%) affected the survival (p-value = 0.003) of breast cancer (Figure 3B,B’). This evidence concerns the gene ESR1 and breast carcinoma.