IFNG and infection: In agreement with the above-mentioned TLR involvement in PV induction of type I IFN production by PBMCs, an H-1PV mutant armed with CpG motifs proves to be more effective than the wild-type virus in triggering antigen-presenting and T cell activation, and IFN-γ, IL-2 and type I IFN release after infection of human PBMCs [15].