We found that RASSF1A and CCND2 DNA methylation levels in HCC primary tissues was significantly higher than in the adjacent peritumoral tissues (39.8±24.3 vs. 16.21±7.2, p<0.0001 and 20.22±2.18 vs. 9.43±1.06, p<0.0001, respectively, see Fig 3). Here, RASSF1 is linked to hepatocellular carcinoma.