As in the osteonecrosis mice, dexamethasone concentrations were higher in mice receiving asparaginase (median 61.2 nM, IQR 32–81.5 nM) compared to mice receiving dexamethasone alone (median 19.2 nM, IQR 13.5–32.1, p = 8.5x10-4). The gene discussed is ASPG; the disease is osteonecrosis.