Kitamura et al. also reported that BPAF (EC50 = 0.05 μM) has more potent estrogenic activity than BPA (EC50 = 0.63 μM) in MCF-7 ER+ breast cancer cells, indicated by increased ER/estrogen response element (ERE)-mediated transcriptional activity [14]. Here, ESR1 is linked to breast cancer.