These include S100 family members (S100A7, S100A8, S100A9, and S100A7A), DEFB4A, the ISGs OASL and OAS2, and KRT16. The shared increased expression of antibacterial and antiviral proteins by HS lesions and wounded skin suggests that they are carrying out similar antimicrobial programs. Here, S100A7A is linked to histiocytic sarcoma.