Consistent with this result, pathological scoring of tumor sections from Oct1+/+, Oct1+/fl, and Oct1fl/fl Lrig1-CreERT2 mice with heterozygous Apcfl indicated that despite the increased tumor incidence with Oct1 knockout, there were no significant differences in tumor grade or area (Fig 6F and 6G). This evidence concerns the gene LRIG1 and neoplasm.