It triggers a cascade of response, from cell growth to survival and motility, that drive tumor initiation to progression.8 Recently, we discovered that a germline variant in PKN1 gene might perturb the PKN1/FAK/PI3K/AKT pathway and lead to pancreatic tumorigenesis.9 Our study bridged the core elements of PI3K‐AKT signaling with PKN1/FAK, and highlighted the role of the germline variant on this pathway played in PC development. This evidence concerns the gene PIK3CD and pachyonychia congenita.