It is well recognized that the PI3K‐AKT signaling plays critical roles in metastasis of cancers including PC.27, 28, 29, 30 It promotes cellular events such as invasion, migration and epithelial‐mesenchymal transition via regulation of different transcription factors.31, 32, 33PIK3R1, which encodes the 85 kD regulatory subunit of PI3K, functions primarily as a regulator of the p110α catalytic product. Here, PIK3CD is linked to pachyonychia congenita.