We found that increased concentration of CA125 was independently associated with log10 (Il-6) (β = 11.022), history of hospitalization for HF (β = 4.619), log10 (NT-proBNP) (β = 4.416) and age (β = 3,93 for 10 years), as shown in Figure 2. This evidence concerns the gene NPPB and hydrops fetalis.