HMOX1 and colorectal cancer: In colorectal cancer, Nrf2-mediated heme oxygenase-1 (HO-1) overexpression result in cell proliferation and apoptosis resistance, and administering a high dose inhibits Nrf2 nuclear localization, cells expressing high amounts of Nrf2 and Nrf2, Nrf2 entry into the nucleus, Nrf2 binding to ARE, and HO-1-ARE promoter activity, inducing cell apoptosis [109].