Expression of the YAP-S127A or NLS-YAP-5SA transgene (bovine Krt5 promoter-driven transgene with all five serine phosphorylation sites mutated and its N-terminus fused to a NLS; hereafter referred to as K5/NLS-YAP-5SA) both caused severe tissue dysplasia in adult epidermis that eventually progressed to tumour-like masses resembling cSCCs [99,146]. This evidence concerns the gene KRT5 and neoplasm.